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Table 3 Genes associated with hepatic diseases and liver cancer development in mouse primary hepatocytes treated with 100 μM of 3 drugs for 24 hours (based on Ingenuity Pathway Analysis)

From: Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor α agonists

Gene symbol Gene description Locus link ID Beza Feno WY
    fc p fc p fc p
Hepatic diseases        
Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 18670 1.72 0.006 2.06 0.029   
Acox1 acyl-Coenzyme A oxidase 1, palmitoyl 11430 2.91 0.019 3.01 0.012   
Fabp1 fatty acid binding protein 1, liver 14080 27.80 0.001 34.35 0.004 20.96 0.014
Hadha hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit 97212 1.95 0.035 1.81 0.002 1.92 0.000
Insig1 insulin induced gene 1 231070 1.68 0.001    1.64 0.000
Scd stearoyl-Coenzyme A desaturase 1 20249 5.50 0.004 4.51 0.023   
Liver cancer development        
Angptl4 angiopoietin-like 4 57875 2.24 0.009 1.87 0.017 2.28 0.011
Bnip3 BCL2 19kDa-interacting protein 1 12176 1.97 0.014    2.31 0.036
Dbi diazepam binding inhibitor 13167 1.88 0.006 1.82 0.005 1.68 0.035
Fabp1 fatty acid binding protein 1, liver 14080 27.80 0.001 34.35 0.004 20.96 0.014
Fabp2 fatty acid binding protein 2, intestinal 14079 2.88 0.020 2.91 0.014   
Fasn fatty acid synthase 14104 2.03 0.014 1.89 0.015 1.72 0.000
Hif1a hypoxia inducible factor 1, alpha subunit 15251    1.70 0.012 1.64 0.033
Lgals3 lectin, galactose binding, soluble 3 16854 1.89 0.023    2.05 0.000
Ly6d lymphocyte antigen 6 complex, locus D 17068 5.21 0.012 4.23 0.000 5.56 0.000
Mgll monoglyceride lipase 23945 3.51 0.028 3.78 0.013 3.34 0.008
Serpine1 serine peptidase inhibitor, clade E, mem1 18787 2.35 0.016    2.52 0.013
  1. (fc, Fold change; p, P-value; Beza, bezafibrate; Feno, fenofibrate; WY, WY-14,643)