Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor α agonists

Table 3 Genes associated with hepatic diseases and liver cancer development in mouse primary hepatocytes treated with 100 μM of 3 drugs for 24 hours (based on Ingenuity Pathway Analysis)

Gene symbol	Gene description	Locus link ID	Beza		Feno		WY
			fc	p	fc	p	fc	p
Hepatic diseases
Abcb4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	18670	1.72	0.006	2.06	0.029
Acox1	acyl-Coenzyme A oxidase 1, palmitoyl	11430	2.91	0.019	3.01	0.012
Fabp1	fatty acid binding protein 1, liver	14080	27.80	0.001	34.35	0.004	20.96	0.014
Hadha	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit	97212	1.95	0.035	1.81	0.002	1.92	0.000
Insig1	insulin induced gene 1	231070	1.68	0.001			1.64	0.000
Scd	stearoyl-Coenzyme A desaturase 1	20249	5.50	0.004	4.51	0.023
Liver cancer development
Angptl4	angiopoietin-like 4	57875	2.24	0.009	1.87	0.017	2.28	0.011
Bnip3	BCL2 19kDa-interacting protein 1	12176	1.97	0.014			2.31	0.036
Dbi	diazepam binding inhibitor	13167	1.88	0.006	1.82	0.005	1.68	0.035
Fabp1	fatty acid binding protein 1, liver	14080	27.80	0.001	34.35	0.004	20.96	0.014
Fabp2	fatty acid binding protein 2, intestinal	14079	2.88	0.020	2.91	0.014
Fasn	fatty acid synthase	14104	2.03	0.014	1.89	0.015	1.72	0.000
Hif1a	hypoxia inducible factor 1, alpha subunit	15251			1.70	0.012	1.64	0.033
Lgals3	lectin, galactose binding, soluble 3	16854	1.89	0.023			2.05	0.000
Ly6d	lymphocyte antigen 6 complex, locus D	17068	5.21	0.012	4.23	0.000	5.56	0.000
Mgll	monoglyceride lipase	23945	3.51	0.028	3.78	0.013	3.34	0.008
Serpine1	serine peptidase inhibitor, clade E, mem1	18787	2.35	0.016			2.52	0.013

(fc, Fold change; p, P-value; Beza, bezafibrate; Feno, fenofibrate; WY, WY-14,643)

ISSN: 1471-2105