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Figure 6 | BMC Bioinformatics

Figure 6

From: Nanopore Detector based analysis of single-molecule conformational kinetics and binding interactions

Figure 6

Preliminary results add credence to the hypothesis that the UL state has an unbound terminus, and that while in that state conformational switching may be observable (from [8]). For the molecules and blockades shown (a) above, three are found by NMR to have one dominant ground state (no switching), while one of the molecules is found by NMR to have two dominant low energy states (switching). This corresponds exactly with what has been observed in terms of the existence of fine structure (toggling) in the UL blockade state, as shown in (b).

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