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Table 1 Comparison classes of genes expressed in liver, 24 hr cells and 48 hr cells reveal significant differences between tissue and isolated cells.

From: Comparison of transcriptional responses in liver tissue and primary hepatocyte cell cultures after exposure to hexahydro-1, 3, 5-trinitro-1, 3, 5-triazine

Biological Process Liver 24 hr Cells 48 h Cells
  over/under P-value over/under P-value over/under P-value
Liver and Primary cells       
Signal transduction + 1.02E-21 + 3.71E-14 + 1.29E-10
Cell surface receptor mediated signal transduction + 7.35E-12 + 1.16E-09 + 1.65E-07
Cell communication + 9.37E-09 + 3.93E-06 + 4.89E-03
Neuronal activities + 6.85E-08 + 3.36E-08 + 3.63E-05
G-protein mediated signaling + 9.33E-07 + 1.42E-08 + 2.47E-06
Ion transport + 8.51E-06 + 7.03E-09 + 1.34E-02
Cation transport + 2.84E-05 + 1.52E-07 + 1.21E-02
Synaptic transmission + 1.71E-04 + 8.40E-04 + 4.46E-02
Developmental processes + 1.43E-05 + 1.71E-04 + 3.17E-01
Protein biosynthesis - 1.68E-10 - 2.15E-09 - 1.00E+00
Cell adhesion + 6.52E-03 + 4.22E-03 + 1.00E+00
Liver only       
Electron transport - 4.11E-09 - 5.13E-02 - 6.33E-01
Lipid, fatty acid and steroid metabolism - 4.38E-05 + 1.00E+00 - 1.00E+00
Steroid metabolism - 1.56E-04 - 1.00E+00 - 1.00E+00
Ligand-mediated signaling + 3.48E-04 + 1.07E-01 + 1.00E+00
Fatty acid metabolism - 7.41E-04 - 1.00E+00 - 1.00E+00
Coenzyme and prosthetic group metabolism - 1.45E-02 - 1.00E+00 + 1.00E+00
Oxidative phosphorylation - 2.40E-02 - 7.57E-01 - 1.00E+00
Protein phosphorylation + 3.10E-02 - 1.00E+00 - 1.00E+00
Cell adhesion-mediated signaling + 3.80E-02 + 3.37E-01 + 1.00E+00
Primary cells       
Protein metabolism and modification - 6.79E-02 - 2.47E-04 - 3.27E-03
Transport + 6.85E-02 + 4.22E-06 + 1.33E-02
Protein folding - 1.11E-01 - 1.94E-03 - 1.00E+00
General vesicle transport - 1.00E+00 - 4.31E-02 - 1.00E+00
Intracellular protein traffic - 1.00E+00 - 1.12E-03 - 1.00E+00
Nucleoside, nucleotide and nucleic acid metabolism - 1.00E+00 - 1.68E-02 - 1.00E+00
Proteolysis - 1.55E-01 - 1.00E+00 - 4.39E-02
Blood circulation and gas exchange - 1.00E+00 + 6.59E-01 + 8.90E-03
  1. Each list of genes present in liver or cells was compared to the reference list of all possible genes detectable by the microarray using the binomial test (18) for each molecular function, biological process, or pathway term in PANTHER http://www.pantherdb.org. An over (+) or under (-) representation of PANTHER classification categories was considered significant when P-value < 0.05.