Comparison of transcriptional responses in liver tissue and primary hepatocyte cell cultures after exposure to hexahydro-1, 3, 5-trinitro-1, 3, 5-triazine

Table 2 Biological functions identified by GO term enrichment as uniquely affected by RDX in different treatments.

Liver 24 hr after exposure	EASE score	24 hr exposure of primary hepatocyte cells	EASE score	48 hr exposure of primary hepatocyte cells	EASE score
metabolism	9.00E-04	pathogenesis	2.30E-03	physiological process	3.75E-02
lipid metabolism	9.00E-04	lipid transport	1.78E-02	perception of abiotic stimulus	4.14E-02
fatty acid metabolism	5.50E-03	amino acid metabolism	2.77E-02	protein metabolism	4.27E-02
carboxylic acid metabolism	5.60E-03	energy derivation by oxidation of organic compounds	3.22E-02
glutathione conjugation reaction	7.00E-03	cholesterol metabolism	3.33E-02
ubiquitin-dependent protein catabolism	1.32E-02	amino acid and derivative metabolism	3.36E-02
lipid biosynthesis	1.88E-02	RNA processing	3.90E-02
sodium ion transport	3.47E-02
blood pressure	4.00E-02

Data sets were comprised of significantly changed genes as identified by ANOVA in all doses within a tissue or cell exposure time. An enrichment of terms was considered significant when EASE scores were less than 0.05 and a within system false discovery rate was less than 0.125.

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