Table 1 Unique features of human PPI databases
From: An evaluation of human protein-protein interaction data in the public domain
Number of unique human PPIs | Number of proteins | PPI data | Unique features | Download options | PSI-MI compatibility | Download version number | |
|---|---|---|---|---|---|---|---|
HPRD | 36,617 | 9,427 | Experimental | Protein annotations are included (e.g. PTMs, substrate information, tissue expression, disease association, protein complexes, subcellular localization). Signal transduction pathways | Yes | Yes | Release 6 |
BIND | 6,621 | 3,887 | Experimental | Protein complexes, biological pathways, non-protein interactions, Data for >1473 organisms | Yes | Yes | 20060525 |
DIP | 1,067 | 804 | Experimental | PPIs for other organisms, protein complexes | Yes | Yes | Hsapi20060402 |
MINT | 11,367 | 4,975 | Experimental | PPIs for other organisms, non-protein interactions | Yes | Yes | Version 18 |
PDZBase | 101 | 115 | Experimental | PPIs involving PDZ domains. Prediction of residues that interact. | No | No | October 2, 2006 |
MIPS | 346 | 405 | Experimental | PPIs for other organisms | Yes | Yes | October 2, 2006 |
IntAct | 10,244 | 4,614 | Experimental | Protein complexes, PPIs for other organisms, non-protein interactions, provides web based applications, ProViz and Hierarch View, for visualization of interactions | Yes | Yes | 2006-09-22 |
AfCS | Mostly mouse interactions | Mostly mouse proteins | Experimental | Protein annotations are included (e.g. function, subcellular localization, orthologs, tissue expression, mouse knockout phenotype information, PTMs) | No | No | - |
REACTOME | 5,960 | 970 | Experimental, automated and predicted | Biological pathways for several organisms. Navigation through reactions in biological pathways and visualizing connections between them | Yes | No | Version 18 |