Figure 1
From: Large-scale analysis of antigenic diversity of T-cell epitopes in dengue virus
Definition of antigenically redundant sequence. A) The three sequences (NCBI GI no.: 1854039, 17129648 and 37963458) are each unique, and residues that vary among them are shown. B) Overlapping 9-mers generated from the three unique sequences represent all the inherent antigenic variations, with respect to potential 9-mer T-cell epitopes. Although the three sequences are each unique, they share identical 9-mers. 9-mers shown in uppercase are those with an identical match in two of the unique sequences analyzed, while those in bold uppercase have an identical match in all three sequences; unique 9-mers are shown in lowercase. All the 9-mers in sequence 1854039 have a match in at least one of the other two sequences; thus, the antigenic diversity of this sequence can be covered by the other two sequences combined, rendering the sequence 1854039 antigenically redundant. Hence, the minimal number of sequences required to represent antigenic diversity for this dataset is two.