Table 4 Top 20 predicted Dsg3 peptide sequences binding to DQB1*0503 and DRB1*0402.
Rank | DQB1*0503 | DRB1*0402 | ||||
|---|---|---|---|---|---|---|
Peptide | Sequence | Predicted B.E. (kJ/mol) | Peptide | Sequence | Predicted B.E. (kJ/mol) | |
1 | Dsg3 627–641 | GLLLLLLAPLLLLT C | -39.23 | Dsg3 601–615 | TTSPGTRYGRP HSGR | -34.64 |
2 | Dsg3 626–640 | LGLLLLLLAPLLL LT | -38.43 | Dsg3 263–277 | NFPMFRDSQY SARIE | -33.86 |
3 | Dsg3 624–638 | LLLGLLLLLLAPL LL | -37.87 | Dsg3 844–858 | SFLDSLGPKF KKLAE | -33.46 |
4 | Dsg3 629–643 | LLLLLAPLLLLT CDC | -37.82 | Dsg3 264–278 | FPMFRDSQYS ARIEE | -33.22 |
5 | Dsg3 625–639 | LLGLLLLLLAPLL LL | -37.65 | Dsg3 599–613 | YPTTSPGTRY GRPHS | -33.10 |
6 | Dsg3 628–642 | LLLLLLAPLLLLT CD | -37.47 | Dsg3 352–366 | KAEFHQSVISRYRVQ | -32.88 |
7 | Dsg3 620–634 | AIGLLLLGLLLL LLA | -36.48 | Dsg3 598–612 | SYPTTSPGTR YGRPH | -32.76 |
8 | Dsg3 623–637 | LLLLGLLLLLLAPLL | -36.44 | Dsg3 442–456 | AEIKFVKNMNRDST F | -32.60 |
9 | Dsg3 618–632 | PAAIGLLLLGL LLLL | -36.36 | Dsg3 440–454 | KTAEIKFVKNMN RDS | -32.56 |
10 | Dsg3 293–307 | LDEEYTDNWLA VYFF | -36.28 | Dsg3 439–453 | SKTAEIKFVKNM NRD | -32.36 |
11 | Dsg3 622–636 | GLLLLGLLLLLLA PL | -36.23 | Dsg3 52–66 | VKFAKPCREGEDNS K | -32.13 |
12 | Dsg3 619–633 | AAIGLLLLGLL LLLL | -36.20 | Dsg3 186–200 | EPNHLNSKIAFK IVS | -32.10 |
13 | Dsg3 294–308 | DEEYTDNWLAV YFFT | -36.15 | Dsg3 354–368 | EFHQSVISRY RVQST | -32.10 |
14 | Dsg3 621–635 | IGLLLLGLLLLLLA P | -35.67 | Dsg3 247–261 | LSTQCECNIKVKDV N | -32.08 |
15 | Dsg3 297–311 | YTDNWLAVYFFTSGN | -35.28 | Dsg3 262–276 | DNFPMFRDSQYS ARI | -32.07 |
16 | Dsg3 483–497 | VRVPDFNDNCPTA VL | -35.17 | Dsg3 845–859 | FLDSLGPKFK KLAEI | -32.07 |
17 | Dsg3 616–630 | LGPAAIGLLLLGL LL | -34.86 | Dsg3 954–968 | LLTQNVIVTER VICP | -31.93 |
18 | Dsg3 317–331 | EIQTDPRTNEGILK V | -34.75 | Dsg3 351–365 | NKAEFHQSVISR YRV | -31.87 |
19 | Dsg3 295–309 | EEYTDNWLAVYF FTS | -34.67 | Dsg3 344–358 | KLSIAVKNKA EFHQS | -31.85 |
20 | Dsg3 136–150 | DVEKPLILTVKIL DI | -34.63 | Dsg3 441–455 | TAEIKFVKNMN RDST | -31.72 |