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Table 3 Hit-rate of peak-detection algorithms.

From: LIMPIC: a computational method for the separation of protein MALDI-TOF-MS signals from noise

  

LIMPIC

APEX

CENTROID

CROMWELL

In-vitro proteins

Average number of detected peaks

16

42

62

50

 

Number of peak classes

11

21

27

23

 

Hit-rate

0.69

0.50

0.44

0.44

Human plasma

Average number of detected peaks

146

291

283

172

 

Number of peak classes

62

84

76

60

 

Hit-rate

0.42

0.29

0.27

0.35

  1. LIMPIC, APEX, CENTROID and CROMWELL methods were assessed with respect to the groups of mass spectra obtained from the in-vitro purified protein samples and human plasma samples, respectively. The performances were measured on the basis of a hit-rate parameter; the latter was obtained as a ratio between the number of peak classes, selected on the basis of a PDR larger than 0.5, and the average number of detected peaks.