A multiple alignment showing the common fold specific signals, along with the group specific sub-family function specific signals. Alscript  figure showing a portion of the alignment of representatives of six protein kinase families discussed in the text. The alignment is coloured based on residue conservation: Red and pink – identical and conserved across all families – correspond to fold signals, and blue and green – identical and conserved within a family. Positions predicted to confer specificity for the family  are highlighted in yellow. Deleted regions are indicated by dashes (- - -). Numbers below the alignment correspond to the PDB structure 2f7z.