Figure 1From: HMM-ModE – Improved classification using profile hidden Markov models by optimising the discrimination threshold and modifying emission probabilities with negative training sequencesA multiple alignment showing the common fold specific signals, along with the group specific sub-family function specific signals. Alscript [36] figure showing a portion of the alignment of representatives of six protein kinase families discussed in the text. The alignment is coloured based on residue conservation: Red and pink – identical and conserved across all families – correspond to fold signals, and blue and green – identical and conserved within a family. Positions predicted to confer specificity for the family [35] are highlighted in yellow. Deleted regions are indicated by dashes (- - -). Numbers below the alignment correspond to the PDB structure 2f7z.Back to article page