Figure 2

Relationship between the bin framework and the energy landscape. An illustration of how conformations at a given state of the bin framework relate to the energy landscape of a given protein. $\widehat{E}$ is the best solution quality found so far and serves as an estimate of the ground state energy, ΔE is the energy range of interest, and conformations within this range are binned. Each bin i has energy threshold $E_i^{+}$, diversity threshold HD _i , and energy window ΔE _i .