Contingency table used to perform a Fisher exact test of homogeneity, among different categories of binding sites (based on ligand types), of the fraction of statistically significant overlaps (i.e. P-value ≤ 0.05, see Methods for meaning of the P-value) between destabilizing regions and known binding sites. Abbreviations used: Nu, nucleic-acid; Po, polysaccharide; Pr, protein; Pe, peptide; Sm, small compound; Me, metal ion; Li, lipid; Sig. Overlap, statistically significant overlap; No. Overlap, statistically non-significant or absent overlap. Calculated expected numbers of statistically significant overlaps are given between brackets, below the corresponding observed numbers.