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Table 4 Overlap between destabilizing regions and binding sites according to ligand type

From: Relating destabilizing regions to known functional sites in proteins

Ligand type Nu Po Pr Pe Sm Me Li Total
Sig. Overlap 1 (5.7) 8 (6.2) 7 (9.6) 5 (5.7) 19 (13.6) 5 (4.5) 2 (1.7) 47
No. Overlap 9 (4.3) 3 (4.8) 10 (7.4) 5 (4.3) 5 (10.4) 3 (3.5) 1 (1.3) 36
Total 10 11 17 10 24 8 3 83
  1. Contingency table used to perform a Fisher exact test of homogeneity, among different categories of binding sites (based on ligand types), of the fraction of statistically significant overlaps (i.e. P-value ≤ 0.05, see Methods for meaning of the P-value) between destabilizing regions and known binding sites. Abbreviations used: Nu, nucleic-acid; Po, polysaccharide; Pr, protein; Pe, peptide; Sm, small compound; Me, metal ion; Li, lipid; Sig. Overlap, statistically significant overlap; No. Overlap, statistically non-significant or absent overlap. Calculated expected numbers of statistically significant overlaps are given between brackets, below the corresponding observed numbers.