Ligand type | Nu | Po | Pr | Pe | Sm | Me | Li | Total |
|---|
Sig. Overlap | 1 (5.7) | 8 (6.2) | 7 (9.6) | 5 (5.7) | 19 (13.6) | 5 (4.5) | 2 (1.7) | 47 |
No. Overlap | 9 (4.3) | 3 (4.8) | 10 (7.4) | 5 (4.3) | 5 (10.4) | 3 (3.5) | 1 (1.3) | 36 |
Total | 10 | 11 | 17 | 10 | 24 | 8 | 3 | 83 |
- Contingency table used to perform a Fisher exact test of homogeneity, among different categories of binding sites (based on ligand types), of the fraction of statistically significant overlaps (i.e. P-value ≤ 0.05, see Methods for meaning of the P-value) between destabilizing regions and known binding sites. Abbreviations used: Nu, nucleic-acid; Po, polysaccharide; Pr, protein; Pe, peptide; Sm, small compound; Me, metal ion; Li, lipid; Sig. Overlap, statistically significant overlap; No. Overlap, statistically non-significant or absent overlap. Calculated expected numbers of statistically significant overlaps are given between brackets, below the corresponding observed numbers.
