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Table 3 Discriminative reactions from a t-test. .

From: Using gene expression data and network topology to detect substantial pathways, clusters and switches during oxygen deprivation of Escherichia coli

Rank Reaction Regulation P-value Found also with our technique
1 formate hydrogenlyase complex 1 2.99E-19 Yes
2 FocA formate FNT transporter 1 3.18E-16 Yes
3 pyruvate formate-lyase 1 7.29E-15 Yes
4 aminomethyltransferase -1 3.33E-14 Yes
5 gcv system -1 1.67E-12 Yes
6 3-methyl-2-oxobutanoate hydroxymethyltransferase 1 3.92E-12 Yes
7 glycine dehydrogenase (decarboxylating) -1 5.52E-12 Yes
8 PFL-deactivase 1 2.01E-11 Yes
9 acetaldehyde dehydrogenase 1 2.01E-11 Yes
10 pyruvate kinase 1 2.55E-11 No
11 fumarate reductase 1 2.69E-11 Yes
12 enolase 1 2.87E-11 Yes
13 N-acetylmuramyl-L-alanine amidase 1 3.10E-11 No
14 formate dehydrogenase 1 3.30E-11 Yes
15 glutamate dehydrogenase (NADP+) 1 4.21E-11 No
16 mannonate dehydratase -1 7.97E-11 Yes
17 pyruvate formate-lyase activating enzyme 1 1.91E-10 Yes
18 pyruvate formate-lyase activating enzyme 1 1.91E-10 Yes
19 triose phosphate isomerase 1 2.25E-10 Yes
20 glutamyl-tRNA reductase 1 3.21E-10 Yes
21 histidine-phosphate aminotransferase 1 3.35E-10 Yes
22 2-keto-4-hydroxyglutarate aldolase 1 7.98E-10 Yes
23 2-keto-3-deoxy-6-phosphogluconate aldolase 1 7.98E-10 Yes
24 oxaloacetate decarboxylase 1 7.98E-10 Yes
25 putative NAD+ kinase 1 1.29E-09 No
26 6-phosphofructokinase-1 1 1.29E-09 Yes
27 mannose-6-phosphate isomerase 1 1.37E-09 Yes
28 Outer Membrane Ferrichrome Transport System -1 1.57E-09 Yes
29 NADH oxidoreductase 1 2.19E-09 No
30 isocitrate dehydrogenase kinase -1 4.61E-09 Yes
31 isocitrate dehydrogenase phosphatase -1 4.61E-09 Yes
32 RhtB homoserine Rht Transporter 1 5.70E-09 No
33 histidinol-phosphatase 1 7.39E-09 Yes
34 imidazoleglycerol-phosphate dehydratase 1 7.39E-09 Yes
35 Outer Membrane Ferric Enterobactin Transport System -1 1.49E-08 Yes
36 phosphoenolpyruvate carboxylase 1 2.38E-08 Yes
37 tetrahydrodipicolinate succinylase 1 2.90E-08 Yes
38 imidazole glycerol phosphate synthase 1 3.36E-08 Yes
39 3-hydroxy acid dehydrogenase 1 3.59E-08 Yes
40 branched chain amino acids ABC transporter -1 4.83E-08 Yes
  1. The 40 first ranking reactions when applying a mutant and multiple testing corrected t-test directly without any network information. Shaded rows were found only by this standard method (see text)