Table 2 Breast cancer-related genes. Genes with multivariate expression patterns discovered by the RIT algorithm for the breast cancer data.
Gene | Status | Function | Ref. (PMID) |
|---|---|---|---|
Anln | C | Over-expressed in diverse common human tumors, may have potential as biomarker. | 16203764 |
Aurka | B | Cell cycle-regulated kinase, possible prognostic indicator for patients with breast tumors. | 12833450 |
Aurkb | C | Highly expressed in high-grade gliomas, correlated with malignancy and clinical outcomes. | 15072448 |
Birc5 | B | Prevents apoptotic cell death, differentially expressed in breast cancer. | 16142334 |
Blm | C | Cooperates with p53 in regulation of cell growth, associated with colorectal cancer. | 11781842, 12242432 |
Brrn1 | CC | Required for the conversion of interphase chromatin into condensed chromosomes. | |
Bub1 | C | Mutations in this gene have been associated with aneuploidy and several forms of cancer. | 15931389 |
Ccnb1 | B | Detected in various human breast cancer cell lines and breast tumor tissues. | 11779217 |
Ccnb2 | CC | Essential component of the cell cycle regulatory machinery. | |
Cdc20 | C | Regulatory protein in the cell cycle, associated with gastric cancer. | 15701830 |
Cdc25A | C | Known oncogene, required for progression from G1 to the S phase of the cell cycle. | 14673957 |
Cdc45L | CC | Important for early steps of DNA replication in eukaryotes, loss may affect cell proliferation. | 9660782 |
Cdca8 | CC | Required for stability of the bipolar mitotic spindle. | |
Depdc1 | N | Contains domain of unknown function often present together with the RhoGAP domain. | |
Depdc1B | N | Unknown function, has conserved RhoGAP domain (GTPase-activator protein). | |
Dlg7 | C | Potential oncogenic target of AURKA, may play a role in human carcinogenesis. | 15987997, 12527899 |
Exo1 | C | Possible cancer predisposing gene. | 15328369 |
Fam64A | N | Unknown function. | |
Fbxo5 | CC | Function in ubiquitination, inhibits the anaphase promoting complex. | |
Foxm1 | C | Stimulates the proliferation of tumor cells. | 16489016 |
Gpr116 | N | Has two immunoglobulin-like repeats, may have a role in the immune system. | 12435584 |
H2Afz | C | Chromatin remodeling at the c-myc oncogene involves the local exchange of this histone. | 15878876 |
Hist1H1B | N | Histone protein. | |
Hist1H1E | N | Histone protein. | |
Hist1H4B | N | Histone protein. | |
Kif20A | C | Required for cytokinesis, related to AURKB. Likely to be involved in pancreatic cancer. | 15263015, 15665285 |
Kif23 | CC | Interacts with CYK4, to form the centralspindlin complex. Essential for cell division. | 11782313 |
Kif2C | CC | Important for anaphase chromosome segregation. | |
Kifc1 | CC | Involved in localization of PLK1, AURKB, and CDC14A during anaphase. | 15263015 |
Mad2L1 | C | Mitotic checkpoint gene, involved mainly in colorectal carcinogenesis. | 12970887 |
Nek2 | B | Significantly up-regulated in breast carcinomas. | 15492258 |
Pitrm1 | N | Novel member of the metalloendoprotease superfamily. | 10360838 |
Prr11 | N | Unknown function. Predicted interactions with E2F, which is involved in cancer. | 16437386 |
Pttg2 | C | Potent oncogene, expressed at high levels in various human tumors and tumor cell lines. | 10806349 |
Racgap1 | B | Implicated in in breast cancer cell proliferation | 15863513 |
Rad54L | B | Candidate oncosupressor in breast or colon carcinomas, lymphomas and meningiomas. | 12614485 |
Spbc25 | CC | Essential kinetochore component, significant role in mitotic events | 14699129 |
Stil | C | Involved in mitosis and in increased mitotic activity in tumor cells. | |
Tk1 | C | Marker for non-small cell lung cancer. May be important in epithelial ovarian cancer. | 15809747, 11992400 |
Tpx2 | C | May be important in both progression lung cancer, possible prognostic predictor. | 16489064 |
Ttk | CC | Required for centrosome duplication and for the normal progression of mitosis. | 15618221, 14657364 |
Ube2C | C | Required for destruction of mitotic cyclins. Highly expressed in human primary tumors. | 12874022 |
Ube2S | N | Essential component of the ubiquitin-protein conjugation system. | 15454246 |