The contribution of weak splice sites to GeneSplicerESE's performance. For each threshold that would produce a false negative rate over all splice sites in the test data, we show the difference between the number of false positives that are predicted by GeneSplicer versus GeneSplicerESE. The red plot shows this value for all splice sites, while the green plot shows it for weak splice sites only. See Methods for definition of weak sites. (a) donor sites; (b) acceptor sites.