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Table 1 Experimental evidence for predicted ESE hexamers.

From: A computational survey of candidate exonic splicing enhancer motifs in the model plant Arabidopsis thaliana

9mer ESE ESE Score Mutant ESE Mutant Score Contained Hexamer Motifs
GAAGAAGAA 5 GCAGAAAAA -1 gaagaa, aagaag
TGCTGCTGG 5    tgctgc, gctgct
TGCAGCTGG 5    gcagct, cagctg
GAAGATGGA 5    gaagat, aagatg, gatgga
GAAGGAAGA 5    gaagga, aaggaa, ggaaga
GAGAAGAAG 5    gagaag, gaagaa, aagaag
TTGGAGCAA 5    ttggag, ggagca
AGCTGCTGG 4    agctgc, gctgct
TGCTGGTGG 4    tggtgg
TGCTGCAGG 4    tgctgc, ctgcag
TGCTGCTCG 4    tgctgc, gctgct
TGCTGCTGC 4 TACTTCTGC -3 tgctgc, gctgct
GAGGATTGA 4 GAGAATTGA -1 gaggat
TGCAGATGA 4    gcagat, cagatg
CAAGAAACA 4    aagaaa
GAAGAGAAA 4 GCAGAAAAA -1 aagaga
AAAGGAGAT 4    aaggag, aggaga, ggagat
GAAGAAAGA 4    gaagaa, aagaaa
GAGCAGAAG 4    gagcag
TGCTGCCGC 4    tgctgc
TTGAAGAAG 3 TTGAAAAAG -3 ttgaag, tgaaga, gaagaa, aagaag
TTGAAGCTG 3 TTAAAGCTG -3 ttgaag, tgaagc, gaagct, aagctg
GAAGATTGA 3 GAGAATTGA -1 gaagat
TTTGGTGGA 3    tggtgg, ggtgga
ATGGAGAAA 3 ATTGAGAAA -3 atggag, tggaga, ggagaa
  1. Hexamer motifs that are contained within experimentally confirmed 9-mers with ESE activity (column 5). Experiments to confirm 9-mers are described elsewhere (S. Mount et al., manuscript in preparation). Column 1 shows the containing ESE ninemer, and column 3 shows ninemers without ESE activity, which are situated within 1–2 bp edit distance from the ESE ninemer. The ESE activity of each 9-mer in the table is shown by a score equal to log2(inclusion/skipping) [34].