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Figure 4 | BMC Bioinformatics

Figure 4

From: Multivariate Analysis and Visualization of Splicing Correlations in Single-Gene Transcriptomes

Figure 4

Linkage grids. A, B. Dependency, D(i|j), of splicing at one locus i on a second locus j is plotted for all pairs of loci in the fetal and adult cDNA populations. Independent loci j are on the abscissa. The layout is the same for all grids. Only dependencies at or above 99% significance are displayed. Statistical significance was determined for the two tissue samples either separately (A) of jointly (B). For a given tissue, the same values are plotted in A and B when the linkage is significant in both. Note that a linkage may be significant in one tissue but not both or vice versa. C. The linkage change index, S D (left), measures the extent of change in linkage at a pair of loci in a single parameter. Only changes significant at or above 99% are shown. The right panel plots the magnitude of the linkage vector, |D|, which gives an indication of the overall level of linkge at each pair of loci. The color scale ranges from -0/15 to +0.15 on the top four grids and from -1.4 to +1.4 on the bottom left. Some cell values fall outside the indicated range in order to improve the dynamic range overall. Plus signs (+) indicate these saturated cells.

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