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Figure 6 | BMC Bioinformatics

Figure 6

From: Hinge Atlas: relating protein sequence to sites of structural flexibility

Figure 6

Since active sites residues are enriched in hinges, we performed a separate conservation check on hinge residues in the 94 Hinge Atlas proteins with CSA annotation. We found that even in this set, the least conserved 1/5th of amino acids in each protein tended to contain significantly more hinge residues. The fourth bin was sparse in hinge residues, but at a p-value of 0.043, the significance of this was marginal.

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