Hinge Atlas: relating protein sequence to sites of structural flexibility

BMC Bioinformatics

Table 10 The hinges within the computer annotated set comprise a distinct population from the rest of the set (p-value = 0.017).

	Computer annotated set Hinge vs. non-hinge residues	Hinge Atlas Hinge vs. non-hinge residues	Hinge Atlas hinges vs. Computer annotated hinges
Chi-square	34.37	99.01	31.84
DOFs	19	19	19
p-value	0.017	<10^-4	0.03

The same is true for the Hinge Atlas set.
Hinges in the Hinge Atlas are likely to be a distinct population from hinges in the computer annotated set (p-value 0.03); therefore for future studies one or the other should be used, and we recommend that it be the Hinge Atlas.

ISSN: 1471-2105