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Table 4 Hinge frequency of occurrence in various physicochemical classifications

From: Hinge Atlas: relating protein sequence to sites of structural flexibility

Category Amino acids Hinge Residues (count) All residues (count) Hinge Residues (expected) HI P-value
Aliphatic I, L, V 144 11915 190 -0.120 5.9·10-05
Aromatic H, F, W, Y 82 5718 91 -0.0454 0.14
  A, C, G, H, I, L, K,      
Hydrophobic M, F, T, W, Y, V 521 35278 562 -0.0326 0.0023
Negative D, E 102 6774 108 -0.0242 0.29
Charged R, D, E, H, Y 212 13931 227 -0.0196 0.24
Positive R, H, Y 110 7157 114 -0.0153 0.37
  R, N, D, E, Q, H, Y,      
Polar S, T, W, Y 488 29427 468 0.0178 0.096
  A, N, D, C, G, P, S,      
Small T, V 502 28430 453 0.0450 0.00041
Tiny G, A, S 253 12247 195 0.113 0.0000023