Comparison of the parameter scores optimized using the 344 parameter closed set with maximum (x-axis) and total (y-axis) score detection rules. Reported scores are the averages of the GA runs after the infrequently occurring parameter values are discarded during analysis. Histogram diagram reports the score distribution of the parameters that can be optimized in the simulations. Each (x,y) entry in this histogram plot reports the number of parameters that has mean values of x and y when the maximum- and total-score detection rule was used in the optimization, respectively. The maximum value of the color scale is lowered from 67 to 20 to enhance the contrast between the histogram points. The yeast MIPS dataset compiled by Jansen et al. was used.