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Table 2 In order to test our approach for a large number of TF-gene interactions that might be suggested by sequence analysis or uncertain experimental data, we increased the number of interactions systematically by introducing additional random interactions.

From: Transcriptional regulatory network refinement and quantification through kinetic modeling, gene expression microarray data and information theory

 

T1

T2

T3

T4

T5

T6

T7

T8

T9

T10

G1

-1

1

-1

1

1

1

1

-1

-1

-1

G2

1

-1

1

-1

-1

1

1

-1

1

1

G3

1

1

-1

-1

-1

-1

1

1

1

1

G4

1

1

-1

-1

1

-1

-1

1

-1

-1

G5

1

1

1

-1

-1

-1

-1

-1

1

-1

G6

-1

-1

1

1

-1

-1

1

1

-1

1

G7

1

-1

1

-1

1

-1

-1

-1

-1

1

G8

1

-1

1

1

-1

-1

-1

-1

1

1

G9

1

1

-1

-1

-1

1

1

-1

-1

1

G10

-1

1

1

1

-1

-1

1

1

-1

-1

G11

-1

-1

-1

1

-1

1

-1

1

-1

1

G12

-1

-1

1

1

1

1

-1

1

-1

1

G13

1

1

1

1

1

-1

1

-1

1

1

G14

1

-1

-1

-1

1

1

-1

1

-1

-1

G15

-1

1

1

-1

1

-1

- 1

1

1

1

G16

-1

1

-1

1

1

1

1

-1

-1

-1

G17

1

1

1

-1

-1

1

1

1

-1

1

G18

1

1

1

-1

-1

1

1

1

-1

1

G19

1

-1

1

-1

-1

-1

- 1

1

1

1

G20

-1

1

1

1

-1

1

- 1

1

1

1

  1. In the original matrix, there are 34 nonzero elements whereas in the augmented full matrix there are 200 nonzero elements. The challenge is to identify the actual operating TRN.