Figure 4

The effect of the number of simulation repeats on haplotype block characteristics under different block definitions: θ profiles versus the number of repeat times (n). The sample size (x) was adjusted by fixing it at 725 (solid lines) or 50 (dashed lines). The labels of analyzed SNPs intervals are identical to those in Figure 1. The number of repeat times (n) is shown on the horizontal axis. The simulation was repeated 10,000 times (N = 10,000) from 1, 100, 500, 1,000, 2,000, 3,000, 4,000, 5,000, and 7,500 times. θ profiles (the ratio of times to N times when simulating the transition zone of haplotype block) are shown on the vertical axis. The three labels represent different haplotype block definitions: blue square, Kamatani's method; green triangle, Gabriel's method; red diamond, four-gamete test.