Figure 1From: A Three Stage Integrative Pathway Search (TIPS©) framework to identify toxicity relevant genes and pathwaysCytotoxicity (LDH release). Confluent HepG2 cells exposed to different types of fatty acids (0.7 mM, complexed to 4% w/v BSA) and TNF-α for 24 and 48 hours. X-axis labels indicate the TNF-α concentration in ng/ml and the medium employed in each condition. Data expressed as averages of nine samples +/- s.d. from three independent experiments. a, Significant medium effect, P < 0.05 relative to control (BSA medium with no TNF-α); b, Significant TNF-α effect within a treatment, P < 0.05 compared to corresponding medium with no TNF-α exposure. TNF-α concentrations are in ng/ml.Back to article page