Skip to main content
Figure 10 | BMC Bioinformatics

Figure 10

From: A Three Stage Integrative Pathway Search (TIPS©) framework to identify toxicity relevant genes and pathways

Figure 10

The framework to integrate gene expression and metabolic profiles. The relevancy of each gene to LDH release was first evaluated with GA/PLS. Genes with higher frequencies were considered to be more relevant. The frequencies and profile of the LDH release were then used to constrain the ICA model to extract an independent component that represents the cellular process. The genes in the independent component with high coefficients were subjected to BN analysis.

Back to article page

BMC Bioinformatics

ISSN: 1471-2105

Contact us