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Figure 7 | BMC Bioinformatics

Figure 7

From: A Three Stage Integrative Pathway Search (TIPS©) framework to identify toxicity relevant genes and pathways

Figure 7

Effect of palmitate and TNF-α on Bcl-2 expression measured by western blotting. (A) TNF-α supplementation at 20–100 ng/ml downregulated Bcl-2 in the control, palmitate, and oleate cultures. Similarly, palmitate downregulated Bcl-2 protein expression level as compared to the control and oleate cultures. (B) Effect of PKR inhibition on Bcl-2 level in the palmitate cultures. PKR inhibitor (6 μM) increased the expression of Bcl-2 in palmitate cultured cells.

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