Skip to main content

Table 2 Simulating genetic perturbation and its effects on LDH release

From: A Three Stage Integrative Pathway Search (TIPS©) framework to identify toxicity relevant genes and pathways

  

Probability of LDH Release

Gene

Level

Low

High

SCD

low

0.33

0.67

 

high

0.65

0.35 ↓

NF-KB

low

0.47

0.53

 

high

0.77

0.23↓

PKR

low

0.65

0.25↓

 

high

0.57

0.43

  1. The probability of LDH release taking on a high or low level in the palmitate cultures. BN inference was used to conduct the simulations of up-regulation of SCD, down-regulation of PKR, and up-regulation of NF-KB. "↓" indicates decreased probability and "↑" indicates increased probability.
Back to article page

BMC Bioinformatics

ISSN: 1471-2105

Contact us