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Table 3 Simulating down-regulation of PKR and its effects on Bcl-2

From: A Three Stage Integrative Pathway Search (TIPS©) framework to identify toxicity relevant genes and pathways

  

Probability of Bcl-2 level

Gene

level

Low

High

 

high

0.55

0.45

PKR

low

0.44

0.56 ↑

  1. The probability of Bcl-2 taking on a high or low level in the palmitate cultures. BN inference was used to conduct the simulations of down-regulation of PKR. "↓" indicates decreased probability and "↑" indicates increased probability. This was validated experimentally as shown in Figure 7.