Skip to main content

Table 4 Simulating down-regulation of PKC-δ and its effects on NF-κβ.

From: A Three Stage Integrative Pathway Search (TIPS©) framework to identify toxicity relevant genes and pathways

  

Probability of NF-κβ activation

Gene

level

Low

High

 

high

0.39

0.61

PKC-δ

low

0.51

0.49 ↓

  1. The probability of NF-κβ taking on a high or low level. The model predicts that a down-regulation in PKC-δ will decrease the probability of NF-κβ taking on a high value. This was validated experimentally and shown in Figure 9. "↓" indicates decreased probability and "↑" indicates increased probability.
Back to article page

BMC Bioinformatics

ISSN: 1471-2105

Contact us