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Figure 6 | BMC Bioinformatics

Figure 6

From: Recruitment of rare 3-grams at functional sites: Is this a mechanism for increasing enzyme specificity?

Figure 6

(A) Identification of c-Src unique n-grams. c-Src inactive conformation (PDB:2SRC [58]) is shown as a ribbon diagram (white), the AMP-PNP as a stick model (orange), the phosphotyrosines Y416 and Y527 in space-filling representation, and SH2-kinase domain linker (wheat). The most unique residues are shown as stick model along with their side chains. All ribbon diagrams are drawn using Pymol [59]. (B) C-Src scarcity scores. 111 human Src homologous proteins (E value < 6.10-57) were used in calculations. The abscissa represents the residue index and the ordinate the scarcity score. Filled circles refer to top ranking 32 amino acids colored in panel A, most of which are functional and conserved despite being highly rare in the UniProt. (C) PROSITE motifs. Scanning the c-Src sequence against the PROSITE database reveals two recognized motifs (magenta) corresponding to the ATP binding site and the catalytic loop.

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