Figure 6
From: A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality
Essential proteins are concentrated in a subset of complexes. The distribution of essential proteins in complexes was compared to a randomized background. The fraction of essential proteins in each complex was calculated, sorted into equal-sized bins, and compared to an expected background generated by randomly assigning essential proteins to the same set of complexes. The log ratio of observed to expected frequency for each bin is plotted here: positive values indicate observed frequency above random; negatives indicate below random. The distribution illustrates the concentration of essential proteins in some complexes, and a corresponding absence of essentials in others. Bars marked with an asterisk represent statistically significant deviations from random expectation (P <10-3).