Figure 4

Contribution of the modules. To examine the contribution of the different modules, we plotted the number of interactions predicted among all LR400 interactions (all interactions predicted using the full predictor that obtain a likelihood ratio of interaction greater than 400) as a function of the minimum likelihood ratio of individual modules (in panel A) or of combinations of modules (in panel B). In the case of combinations of modules (panel B), the minimum likelihood ratio is the product of the likelihood ratios of the modules considered. Thus for example, the product of the expression and orthology ratios is greater than 1 for almost 20000 LR400 interactions and greater than 10 for approximately 10000 LR400 interactions (dark blue diamonds in panel B). E: Expression module, O: Orthology module, C: Combined module, T: Transitive module.