Probabilistic prediction and ranking of human protein-protein interactions

BMC Bioinformatics

Table 3 Prediction accuracy of different combinations of modules

Modules included in prediction
Expression	•				•	•	•				•	•	•		•		•		•
Ortho		•			•			•	•		•		•	•	•	•	•	•	•
Combined			•			•		•		•	•	•		•	•	•	•	•	•
Disorder				•			•		•	•		•	•	•	•			•	•
Transitive																•	•	•	•
Coverage of the Informative Protein Set (%)
	22	23	32	99	40	43	99	49	99	99	57	99	99	99	99	90	95	99	99
Measures of accuracy
ROC50 AUC	0.003	0.018	0.022	0	0.024	0.033	0.003	0.042	0.021	0.030	0.044	0.031	0.024	0.038	0.042	0.071	0.075	0.069	0.072
ROC100 AUC	0.003	0.026	0.032	0	0.030	0.045	0.005	0.054	0.027	0.041	0.058	0.044	0.029	0.049	0.058	0.090	0.094	0.088	0.093
Estimation of number of interactions predicted
posterior odds ratio > 4	0	420	0	0	1050	630	0	2520	0	0	3780	630	0	2888	2520	14200	16590	13400	16800
posterior odds ratio > 2	0	630	1050	0	2520	2100	0	3780	210	2100	7980	2100	1050	4200	5460	21340	24570	21200	24200
posterior odds ratio > 1	0	840	4830	0	5670	7140	0	11760	1890	4200	15330	5460	3990	13125	13860	28500	34780	28600	33180

ISSN: 1471-2105