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Table 6 Exhaustive Search Results and Evolutionary Method Evaluation

From: Accelerated search for biomolecular network models to interpret high-throughput experimental data

  Outputs          
Inputs BRCA1 CDC25B E2F1 CDC2 CDKN1B CCNA2 POLD3 PCNA GADD45A MDM2
BRCA1 0 0 0 0 -3 0 0 0 0 0
CDC25B 0 0 -3 0 0 3 0 0 0 3
E2F1 3 -3 0 0 0 -3 3 3 -3 0
CDC2 3 0 0 0 3 0 0 0 0 -3
CDKN1B -3 0 -3 3 0 0 0 0 3 3
CCNA2 0 3 0 3 3 0 0 0 0 3
POLD3 0 -3 3 0 0 0 0 3 0 -3
PCNA 0 0 3 0 3 0 3 0 0 0
GADD45A -3 0 0 0 3 0 0 0 0 -3
MDM2 -3 3 0 0 0 0 -3 0 -3 0
Fit Error (E) 0.431 0.283 0.117 0.432 0.219 0.222 0.221 0.323 0.508 0.49
Ave. # Gen. 16.5 12.8 13.5 12.5 9.7 10.1 11 14.2 12.8 14.6
Max. # Gen. 34 18 * 17 14 15 19 23 21 20
  1. * For E2F1, in two cases the global minimum error rule set was not found after 50 generations due to convergence to a local minimum with a higher fit error (0.134).