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Table 6 Exhaustive Search Results and Evolutionary Method Evaluation

From: Accelerated search for biomolecular network models to interpret high-throughput experimental data

 

Outputs

         

Inputs

BRCA1

CDC25B

E2F1

CDC2

CDKN1B

CCNA2

POLD3

PCNA

GADD45A

MDM2

BRCA1

0

0

0

0

-3

0

0

0

0

0

CDC25B

0

0

-3

0

0

3

0

0

0

3

E2F1

3

-3

0

0

0

-3

3

3

-3

0

CDC2

3

0

0

0

3

0

0

0

0

-3

CDKN1B

-3

0

-3

3

0

0

0

0

3

3

CCNA2

0

3

0

3

3

0

0

0

0

3

POLD3

0

-3

3

0

0

0

0

3

0

-3

PCNA

0

0

3

0

3

0

3

0

0

0

GADD45A

-3

0

0

0

3

0

0

0

0

-3

MDM2

-3

3

0

0

0

0

-3

0

-3

0

Fit Error (E)

0.431

0.283

0.117

0.432

0.219

0.222

0.221

0.323

0.508

0.49

Ave. # Gen.

16.5

12.8

13.5

12.5

9.7

10.1

11

14.2

12.8

14.6

Max. # Gen.

34

18

*

17

14

15

19

23

21

20

  1. * For E2F1, in two cases the global minimum error rule set was not found after 50 generations due to convergence to a local minimum with a higher fit error (0.134).