Figure 2

Functional and localizational co-occurrence of interacting proteins with respect to their reliability. The proportion of the interacting pairs that co-occur in the same functional and localizational categories, with respect to their reliability measured by semantic similarity, semantic interactivity and co-expression. We used (a) the functional categories on the third level in a hierarchy from MIPS, which includes 170 different functions, and (b) 50 distinct localizational categories from MIPS. The semantic similarity and semantic interactivity provide positive correlations with the co-occurrence in functions and localization.