ROC curves for 8 different algorithms using the combined sporulation and cell-cycle gene expression dataset and the ChIP-chip data of Lee, 2002. KEGG pathways were used as the gold standard. ECIM utilizing both expression and binding data dominated all other algorithms. ROC "spots" for GRAM and SAMBA algorithms were obtained by applying the algorithms using the default parameters. Smaller ROC "spots" for SAMBA were obtained by systematically manipulating algorithm's parameters.