Figure 3

Heatmap of agreement matrix for seven clusters: The agreement matrix for N_S samples is an N_S × N_S matrix whose entries are the fraction of cases across replicates for which two samples fall into the same cluster. Red/green represent high/low fractional values across clustering methods and data perturbation replicates. The normals and the LG1 and LG2 are clearly well separated while the HG1, HG2, HG3 and HG4 separation is weaker. We find that the optimum number of clusters using gap-statistics oscillates between 6 and 7 with the HG3 and HG4 clusters merging at k-6.