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Table 1 Comparison of thresholds obtained by RMT approach and randomization method and their corresponding co-expression networks. The thresholds determined by RMT approach and randomization method on two yeast microarray expression profiles and their corresponding co-expression networks are compared. Abbreviations: MI – mutual information, and Pearson – Pearson correlation coefficient.

From: Constructing gene co-expression networks and predicting functions of unknown genes by random matrix theory

Microarray data

Yeast cell cycle

Yeast environmental stress responses

 

RMT

Randomization

RMT

Randomization

Correlation measure

MI

Pearson

MI

Pearson

MI

Pearson

MI

Pearson

rh

1.17

0.77

1.253065

0.68836

1.361

0.91

0.666697

0.533674

Number of genes

861

966

342

2398

402

523

3883

5266

Number of links

1764

3346

591

15853

4991

7160

625161

1585805

"true" links (%)

57.88

64.94

64.13

52.27

77.28

75.53

32.30

29.86