Figure 2From: Hybrid elementary flux analysis/nonparametric modeling: application for bioprocess controlProposed model-based optimisation scheme. On-line optimisation supported by the hybrid model. The process performance function includes a penalty term that accounts for the risk of model unreliability, i.e., extrapolation outside the model trust region. The parameter estimation as well as the optimisation of the future process course occurs every time a new measurement becomes available.Back to article page