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Table 1 Protein descriptors commonly used for predicting protein functional families.

From: Efficacy of different protein descriptors in predicting protein functional families

Sets Descriptor-sets No. of descriptors (properties) No. of components Type Physicochemical properties Refs
D1 Amino acid composition 1 20 Sequence composition   [23]
D2 Dipeptide composition 1 400 Sequence composition   [24]
D3 Normalized Moreau – Broto autocorrelation 8 240 Correlation of physicochemical properties Hydrophobicity scale, average flexibility index, polarizability parameter, free energy of amino acid solution in water, residue accessible surface area, amino acid residue volume, steric parameters, relative mutability [25, 26]
D4 Moran autocorrelation 8 240 Correlation of physicochemical properties Hydrophobicity scale, average flexibility index, polarizability parameter, free energy of amino acid solution in water, residue accessible surface area, amino acid residue volume, steric parameters, relative mutability [27]
D5 Geary autocorrelation 8 240 Square correlation of physicochemical properties Hydrophobicity scale, average flexibility index, polarizability parameter, free energy of amino acid solution in water, residue accessible surface area, amino acid residue volume, steric parameters, relative mutability [28]
D6 Descriptors of composition, transition and distribution 21 147 Distribution and variation of physicochemical properties Hydrophobicity, Van der Waals volume, polarity, polarizability, charge, secondary structures, solvent accessibility [2-6, 8, 17, 29, 30]
D7 Quasi sequence order 4 160 Combination of sequence composition and correlation of physicochemical Hydrophobicity, hydrophilicity, polarity, side-chain volume [10, 11, 18, 31]
D8 Pseudo amino acid composition 3 298 Combination of sequence composition and square correlation of physicochemical Hydrophobicity, hydrophilicity, side chain mass [23, 32]
D9 Combination of amino acid and dipeptide composition 2 420 Combination of sequence compositions   
D10 Combination of all eight sets of descriptors 54 1745 Combination of all sets