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Figure 2 | BMC Bioinformatics

Figure 2

From: Automated smoother for the numerical decoupling of dynamics models

Figure 2

Result in real data. Illustration of the smoothing procedure applied to in vivo Lactococcus lactis time series for Glucose, Glucose 6-phosphate (G6P), Fructose 1,6-bisphosphate (FBP), 3-Phosphoglycerate (3-PGA), Phosphoenolpyruvate (PEP), and Lactate [16]. The first derivative is shown below the corresponding metabolic time series. The window partitions are shown with distinct colors. It is noteworthy that the shift in noise structure, which segments the signal into smaller temporal windows with noise invariance, is approximately the same for all metabolites except FBP. Since the smoothing procedure is applied independently to each metabolite, this coupling suggests shared dependency on some molecular machinery, which changes when its main substrate, Glucose, is depleted at t ~ 6 min.

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