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Table 1 Accuracy of ASMPKS in the domain identification

From: ASMPKS: an analysis system for modular polyketide synthases

  No of total No of predicted No of correct SP(%) SN(%)
Group 1 906 900 899 99.8 99.2
Group 2 792 779 777 99.7 98.1
Group 3 129 111 110 99.1 85.2
  1. Specificity (SP) = Correct predictions/Total predictions,
  2. Sensitivity (SN) = Correct predictions/Total domains
  3. The group 1 is composed of 906 domains of 20 polyketides, amphotericin, ascomycin, avermectin, epothilone, erythromycin, megalomicin, myxalamid, myxothiazol, niddamycin, nystatin, oleandomycin, pikromycin, pimaricin, pyoluteorin, rapamycin, rifamycin, soraphen, spinosad, stigmatellin, and tylactone, that are included in PKSDB.
  4. The group 2 is composed of 792 domains in modular PKSs of 17 type I polyketides which are aureothin, borrelidin, bryostatin, concanamycin a, coronatine, fk506, fr-008, geldanamycin, herbimyycin a, lankamycin, methymycin, monensin, mycolactone, nanchangmycin, phoslactomycin, rubradirin and vicenistatin.
  5. The group 3 is composed of 129 domains of 5 PKS-NRPS hybrid types which are bacillaene, cryptophycin, lankacidin, leinamycin and pederin.