TY - JOUR AU - Su, Emily Chia-Yu AU - Chiu, Hua-Sheng AU - Lo, Allan AU - Hwang, Jenn-Kang AU - Sung, Ting-Yi AU - Hsu, Wen-Lian PY - 2007 DA - 2007/09/08 TI - Protein subcellular localization prediction based on compartment-specific features and structure conservation JO - BMC Bioinformatics SP - 330 VL - 8 IS - 1 AB - Protein subcellular localization is crucial for genome annotation, protein function prediction, and drug discovery. Determination of subcellular localization using experimental approaches is time-consuming; thus, computational approaches become highly desirable. Extensive studies of localization prediction have led to the development of several methods including composition-based and homology-based methods. However, their performance might be significantly degraded if homologous sequences are not detected. Moreover, methods that integrate various features could suffer from the problem of low coverage in high-throughput proteomic analyses due to the lack of information to characterize unknown proteins. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-8-330 DO - 10.1186/1471-2105-8-330 ID - Su2007 ER -