Figure 6
From: Impact of image segmentation on high-content screening data quality for SK-BR-3 cells
Examples of segmentation-sensitive and resistant cell-body features. Panels (A, B) show dose response of the KS statistic to the compound 17AAG, for the P2A feature in Channel 1, computed using only well-segmented cells (A), or only poorly segmented cells (B). A substantial difference is seen between the two responses for this "sensitive" feature. Panels (C, D) show dose response of KS statistic to the compound 5-FU, for the Average Intensity feature in Channel 3, computed using only well-segmented cells (C), or only poorly segmented cells (D). The two dose responses are similar for this "resistant" feature.