Bridge-PLSR Y-loadings. Bridge-PLSR Y-loadings for a two-component model of the rat-liver data. Each point represents an Y-variable, and the percent explained, validated variance for each response is indicated by the colour-bar on the right. The variables are the design parameters Dose and Time, the concentrations of reduced (RedG) and oxidised (OxG) glutathione levels in the liver, and the concentrations in the blood of sorbitol dehydrogenase (SDH), total bile acids (BILE), alkaline phosphatase (ALP), aspartate aminotransferase serum (AST), alanine aminotransferase (ALT), total protein (TP), albumin (ALB), blood urea nitrogen (BUN), creatinine (CREA) and cholesterol (CHOL). The diagnostic markers for liver injury ALT and AST is highly predictive for the first component, while the second component is related to time since exposure.