Figure 1

(A-B) A schematic defining FragmentDomainI, FragmentDomainU and NOED. In this example, 0 and 2 hours constitute the reference and target, respectively. In panel A the probes and the enrichment regions are represented in red and light blue respectively; in panel B, the enrichment fragments FragmentDomainU: 1, 3, 5, 7: FragmentDomainI:2, 6; NOED:4. (C): This is an IGB visualization of the fragmented enrichment domains as defined in the reference (blue) and target (yellow). The SE graphs represent biological data from 5 replicates each for reference and target. There are three levels of annotation between the reference and target graphs; the annotations in blue and yellow are representative of enrichment fragments unique to the reference and target, respectively; the annotation in red is representative of the intersecting enrichment fragments. Peaks representative of the binding of putative regulatory elements are evident upstream of and at the 5'end of the HIC gene and in the first few exons and in the introns.