Figure 8
From: Single TNFα trimers mediating NF-κ B activation: stochastic robustness of NF-κ B signaling
Evolution of main variables during persistent, 10 hours long stimulation with high dose TNFα = 10 ng/ml. Red line – typical single cell simulation, black line – average over 100 cells. Panel A: Number of active receptors, Panel B: IKKKa level, Panel C: IKKa level, Panel D: Total Iκ Bα, Panel E: Nuclear NF-κ B, Panel F: Iκ Bα gene activity, Panel G: A20 gene activity, Panel H: Iκ Bα mRNA, Panel I: A20 mRNA, Panel J: A20 protein.