Figure 1From: Large scale statistical inference of signaling pathways from RNAi and microarray dataMain idea of the inference framework by Markowetz et al.: A network hypothesis is a directed graph between S-genes. Attached to each S-gene are several E-genes. Knocking down S-gene S2 interrupts signal flow in the downstream pathway, and hence an effect of E-genes attached to S2 and to S1 is expected.Back to article page