Table 1 Six example domain assembly units and their corresponding annotations.

1.

FHA domain (PF00498)

P-cell cycle 4.32*10^-06

Fork head domain (PF00250)

C-nucleus 2.12*10^-02

Protein kinase domain (PF00069)

F-transcription factor activity 4.22*10^-05

2.

Fungal Zn(2)-Cys(6) domain (PF00172)

P-regulation of transcription: 8.33*10^-17

Fungal transcription factor domain (PF04082)

C-nucleus, 5.48*10^-12

Gal4-like dimerization domain (PF03902)

F-transcription regulator, 2.24*10^-26

PAS fold domain (PF00989)

3.

ABC transporter domain (PF00005)

P-transport, 3.02*10^-05

ABC transporter region 1 domain (PF00664)

C-membrane, 4.15*10^-05

ABC transporter region 2 domain (PF06472)

F-ATPase activity, 5.68*10^-23

ABC-2 type transporter (PF01061)

Metal-binding domain in RNase L domain (PF04068)

4Fe-4S binding domain (PF00037)

4.

GTPase of unknown function domain (PF01926)

P-ribosome-nucleus export, 1.51*10^-02

DUF933 domain (PF06071)

C-mitochondrial inner membrane, 3.27*10^-02

TGS domain (PF02824)

F-GTP binding, 9.86*10^-09

GTP1/OBG domain (PF01018)

5.

Helicase conserved C-terminal domain (PF00271)

P-chromosome organization, 5.41*10^-06

SNF2 family N-terminal domain (PF00176)

C-chromatin remodeling complex, 1.77*10^-03

HSA (PF07529)

F-ATPase activity 2.04*10^-07

Chromatin organisation modifier domain (PF00385)

6.

Elongation factor Tu GTP binding domain (PF00009)

P-translation factor activity 1.08*10^-20

Elongation factor Tu domain 2 (PF03144)

C-ribosome 3.71*10^-04

Elongation factor G C-terminus (PF00679)

F-translation 1.33*10^-09

Elongation factor G, domain IV (PF03764)

Elongation factor Tu C-terminal domain (PF03143)

GTP-binding protein LepA C-terminus (PF06421)

Translation initiation factor IF-2, N-term. (PF04760)