Figure 1

Overview of methods. (A) The main method of identifying subsystems only requires a set of attractors (*). These attractors can be found either from a model or directly from experimental data, meaning that a known network topology is not essential. (B) More detailed schematic of the methods, showing the procedures required at each step (given in the Methods section). The attractors are used to find intersection sequences and partition sequences (Stage 1), which are then used to identify subsystems (stage 2). Once the subsystems are identified, regulation sets can be found with the help of a suitable mathematical model.