'Unite and conquer': enhanced prediction of protein subcellular localization by integrating multiple specialized tools

Table 1 Examples of conflicting results from individual prediction tools

Sequence ID¹	Experimentally verified location	Predictions of mitochondrial location by individual LOC-tools^2,3
		TargetP	Subloc	pTARGET	SherLoc	Predotar	MitoProt	CELLO	PProwler	PASUB
YOR297C	Mitochondria	mit	mit	mit	non	non	mit	non	non	mit
YDR378C	Nucleus	mit	mit	non	non	non	mit	mit	non	non

¹ The example sequences are retrieved from the yeast genome database [52]
² For references see text
³ "mit", predicted as mitochondrial protein; "non", predicted as non-mitochondrial protein

ISSN: 1471-2105